Macam Dosis Obat Anti Epilepsi Lengkap
Macam Dosis Obat Anti Epilepsi Lengkap - Salam Farmasi Indonesia, sesuai judul saya akan membagikan sebuah artikel mengenai macam dosis dari obat anti epilepsi, Dari Dosis Lazim, Dosis Maksimal, Dosis Toksik, Dosis Letal dan Indeks Terapi. Berikut Penjelasannya :
DAFTAR OBAT ANTI-EPILEPSI
| No | Nama Obat | Dosis Lazim | Dosis Maksimal | Dosis Toksik | Dosis Letal | Indeks Terapi |
| 1 | Acetazolamide | 250 mg b.d. | 1000 mg setiap hari
dalam dosis terbagi |
- | - | 250 mg – 1 g
- |
| 2 | Carbamazepine | 100-200 mg 1-2 kali
setiap hari |
2000 mg setiap hari
dalam dosis terbagi |
>15 mcg/ml | - | 4-12 mcg/ml
- |
| 3 | Clobazam | 5-10 mg setiap hari | > 60 mg setiap hari | - | - | 30-300 mg/ml
- |
| 4 | Clonazepam | 0,5 mg b.d.s. | 8 mg setiap hari | > 80 mg/ml | - | 20-70 mg/ml
- |
| 5 | Cloxazolam | 12 mg perhari dalam
dosis terbagi |
- | - | - | - |
| 6 | Dantrolene | - | - | - | - | - |
| 7 | Diazepam | 5-10 mg | 300 mg setiap hari | - | - | - |
| 8 | Ethosuximide | 250 mg b.d | 2000 mg setiap hari | - | - | 40-100 mg/ml |
| >150 mg/ml | ||||||
| 9 | Ethotoin | - | - | - | - | - |
| 10 | Ezogabine | 200-400 mg t.d.s | 1200 mg per hari | 2500 mg/hari | 100 mg/kg
(pada hewan uji tikus) |
- |
| 11 | Felbamate | 300 mg t.d.s | 3600 mg dalam dosis
terbagi |
- | - | - |
| 12 | Gabepentin | 200-300 mg t.d.s | 3600 mg setiap hari
dalam dosis terbagi 3 |
- | >8000mg | 2-20 mg/ml
³ 25 mcg/ml |
| 13 | Ganaxolone | - | - | - | - | - |
| 14 | Lacosamide | 50 mg b.d. | 200 mg b.d. | - | - | 5-10 mg/ml
- |
| 15 | Lamotrigine | 25 mg b.d. | 1,5 g b.d. | - | >15 g | 3-14 mcg/ml
- |
| 16 | Levetiracetam | 500 mg b.d. | 3000 mg setiap hari | - | - | 12-46 mg/ml
46 > mg/ml memiliki potensi racun |
| 17 | Mephenytoin | 200 - 600 mg t.d.s | 800 mg per hari | - | - | - |
| 18 | Midazalom | 10 mg p.rn | 20 mg | - | - | - |
| 19 | Nitrazepam | 5 – 10 mg setengah
jam sebelum tidur |
- | - | - | - |
| 20 | Oxcarabazepine | 300 mg b.d. | 1200 mg b.d. | 40mg/ml | - | 3-35 mg/ml
>40 mg/ml (toksik) |
| 21 | Perampanel | 2 mg / 4ml | 6 mg/ 12 ml
4 mg/ 8 ml |
- | - | - |
| 22 | Phenobarbital | 30 mg | 600 mg b.d. | 60 mcg/ml | - | 10-40 mcg/ml |
| 23 | Phenytoin | 150-300 mg | 800 mg b.d. | - | - | 10-20 mg/ml
- |
| 24 | Piracetam | - | - | - | - | 4-50 mg/kg
- |
| 25 | Pregabalin | 25 mg b.d. | 600 mg dalam dosis
terbagi |
10mgc/ml | - | 2-5mcg/ml
- |
| 26 | Primidone | 125 mg sebelum
tidur |
1500 mg b.d | - | LD50
280mg/kg(mus) 1500mg/kg(rat) |
5-12 mg/ml
- |
| 27 | Retigabine | 600-1200 mg t.d.s. | - | - | - | - |
| 28 | Rufinamide | 200mg b.d. | 1600 mg b.d | - | - | 3-30 mg/ml
- |
| 29 | Sodium
Valproate |
300 mg b.d. | 2500 mg | - | - | 50-100mg/L |
| 30 | Stiripentol | 50 mg/kg/day b.d.s /
t.d.s. |
- | - | - | 10-40 mg/L dalam
serum |
| 31 | Talampanel | - | - | - | - | - |
| 32 | Tiagabine | 5 mg b.d. | 30-45 mg | - | - | <235 mg/ml
- |
| 33 | Topiramate | 25 mg | 400 mg dalam dosis
terbagi 2 |
>40mg/ml | 2-5 g perhari | - |
| 34 | Vigabatrin | 500 mg b.d. | 3000 mg | - | - | - |
| 35 | Zonisamide | 50 mg b.d. | 500 mg | - | - | - |
Daftar Pustaka
http://chealth.canoe.com/drug/getdrug/apo-nitrazepam http://pionas.pom.go.id/monografi/topiramat
http://www.epilepsy.ie/assets/48/C824838E-D761-D5A2-840271758447404A_document/Table_of_Anti_Epileptic_Drugs_adults.pdf http://www.healthcare.uiowa.edu/path_handbook/handbook /test3329.html
http://www.rxlist.com/script/main/mobileart-rx.asp?drug=neurontin&monotype=rx-desc&monopage= https://drug.mynahcare.com/drugs/genericdetail/cloxazolam-NTU5 https://lifeinthefastlane.com/ccc/sodium-valproate-overdose/ https://reference.medscape.com/drug/acetazolamide-342809#0 https://reference.medscape.com/drug/potiga-ezogabine-999664#5
https://www.childrensmn.org/ https://www.childrensmn.org/lab/chemistry/tiagabine-(gabitril)-level.pdf https://www.drugbank.ca
https://www.drugs.com/pro/gabapentin.html https://www.epilepsysociety.org.uk/list-anti-epileptic-drugs https://www.epilepsysociety.org.uk/stiripentol http://www.glowm.com/resources/glowm/cd/pages/drugs/m019.html https://www.healthcare.uiowa.edu/ https://www.healthcare.uiowa.edu/path_handbook/handbook/test13.html https://www.healthcare.uiowa.edu/path_handbook/handbook/test2243.html https://www.healthcare.uiowa.edu/path_handbook/handbook/test298.html https://www.healthcare.uiowa.edu/path_handbook/handbook/test3114.html https://www.healthcare.uiowa.edu/path_handbook/handbook/test3329.html https://www.healthcare.uiowa.edu/path_handbook/handbook/test462.html https://www.healthcare.uiowa.edu/path_handbook/handbook/test755.html https://www.helthcare.uiowa.edu/path_hanbook/handbook/test462.html
Data diambil dari banyak sumber, kolom yang kosong bukan berarti tidak ada melainkan sulit untuk ditemukan dengan itu bila ada yang tahu dosis yang kosong tersebut bisa tulis di komentar.
Sekian dari saya mohon maaf bila ada kesalahan, terimakasih telah berkunjung.
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