Macam Dosis Dari Obat Diabetes Militus Lengkap

DOSIS DARI OBAT DIABETES MELITUS

 

No	Nama Obat	Dosis Lazim / hari	Dosis Maksimal (DM)	Dosis toksik (DT)	Dosis Letal	Indeks Terapi
1	Insuline	-	-	-	-	-
2	S0ufonilurea	-	-	-	-	-
3	Klorpropamid	250 mg	500 mg/hari	2.1413 LD50, mol/kg (rat)	LD50 580 mg/kg	-
4	Glikazid	40 mg – 80 mg	240 mg/hari	3000 mg/kg	LD50;> 4 g/kg	-
5	Glibenklamid	2.5 mg - 5 mg	15 mg - 20 mg	1.4243 LD50,	LD50; >20,000	-

				mol/kg	mg/kg [rat] LD50; 3250 mg/kg [tikus]
6	Glipizid	2,5 mg - 5 mg	15 mg - 40 mg	2.1662 LD50, mol/kg	LD50 > 4 g/kg	-
7	Glikuidon	15 mg	60 mg/hari	-	-	-
8	Glimepirid	1 mg	4 mg – 6 mg/hari	-	-	-
9	Tolbutamid	1 gram – 2 gram	3 gram	-	LD50 =2600 mg/kg [tikus]	-
10	Biguanida	-	-	-	-	-
11	Metformin	500 mg	2500 mg	350 mg/kg [Rabbit]	35 g	500 mg
12	Tiazolidindion	-	-	-	-	-
13	Pioglitazone	15 mg – 30 mg	45 mg	-	-	-
14	Rosiglitazon	4 mg	8 mg	-	2.4515 LD50, mol/kg [rat]	-
15	Empagliflozim	10 mg	25 mg	700 mg/kg/day	-	-

				[rabbit]
16	Glyburide	2,5 mg - 5 mg	20 mg	-	LD50; >20.00 mg/kg [rat] LD50; 3250 mg/kg [tikus]	-
17	Glymepiride	1 mg - 2 mg	8 mg	2.4158 LD50, mol/kg	DL50; 50 per ciento (tikus)	-
18	Repaglinide	0,5 mg	20 mg	2.4497 LD50, mol/kg	LD50 >1 g/kg (rat)	-
19	Nateglinide	60 mg	120 mg	2.0362 LD50, mol/kg	-	-
20	Miglitol	75 mg	300 mg	1.7432 LD50, mol/kg	-	-
21	Pioglitazon	15 mg – 30 mg	45 mg	4 mg - 30 mg/tablet	-	-
22	Excenatide	5 mg	10 mg	-	-	-

23	Saxagliptin	2,5 mg - 5 mg	-	-	500 - 850 mg	2,5 - 40 mg
24	Sigtaliptin	100 mg	-	800 mg	500 mg	50 - 200 mg
25	Dulaxlutide	0,75 mg	1,5 mg	-	-	-
26	Liraglutide	0,6 mg	1,2 mg – 1,8 mg	500 mg	800 mg	3 mg
27	Linagliptin	5 mg	2,5 mg	-	0.25 mg/kg	5mg
28	Alogliptin	25 mg	25 mg	12,5 mg/kg	75 mg	12,5 mg
29	Pramlintide asetat	15 mcg	60 mcg	-	120 mcg	30 mcg
30	Canagliflozin	100 mg	300 mg	-	-	100 mg – 300 mg
31	Dafagliflozin	5 mg	10 mg		-	-	5 mg – 10 mg
32	Acarbose	50 mg – 150 mg	200 mg - 400 mg	-		-	100 mg - 300 mg

Daftar Pustaka

www.drugbank.ca
https://www.drugs.com/dosage/acarbose.html
https://www.drugs.com/dosage/dapagliflozin.html
https://www.drugs.com/dosage/canagliflozin.html
https://www.drugs.com/monograph/pramlintide-acetate.html
http://www.drugs.com/dosage//glymepiride.html
http://www.drugs.co.id/repaglinide.html
http://www.drugs.com/nateglinide.html
https://www.drugs.com/dosage/empagliflozin.html
https://www.drugs.com/dosage/glimepiride.html
https://www.drugs.com/dosage/glipizide.html
https://www.drugs.com/dosage/glyburide.html

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By : Dede Taufiq

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